Naturally Occurring Differences in CENH3 Affect Chromosome Segregation in Zygotic Mitosis of Hybrids
Genome elimination mediated by the chimeric “GFP-tailswap” CENH3 is a promising tool for the production of haploids. But, what is the significance of natural variation in CENH3? Shamoni Maheshwari et al. describe in PLoS Genetics (2015) how wide variation in CENH3 is compatible with its essential function, but epigenetically different centromeres do not function well when brought together in a hybrid embryo. This is a Simon Chan legacy paper.