Regeneration of Solanum tuberosum plants from protoplasts induces widespread genome instability

M Fossi, K Amundson, S Kuppu, A Britt, L Comai Plant physiology 180 (1), 78-86

Plants have the remarkable ability to regenerate an entire plant from a single cell. Researchers have long known that this regeneration introduces genetic and phenotypic variation, but the underlying causes remain elusive. Here, we used whole-genome sequencing to document the types and extent of changes to chromosome number and structure that can occur in potato plants that have been regenerated from single cells.