Point Mutations in Centromeric Histone Induce Post-zygotic Incompatibility and Uniparental Inheritance
In a paper published in Plos Genetics the Britt Lab (Sundaram Kuppu et al.) and the Comai lab report a simple non-transgenic approach to the production of haploid inducers. Any of multiple changes in the conserved region of centromeric histone H3 is sufficient to yield a haploid inducer phenotype. This illustrates how simple variation at this locus can result in postzygotic incompatibility. This is a Simon Chan legacy paper.